Key publications from our lab:


Rajgor D., Sanderson T.M., Amici M., Collingridge G.L., and Hanley J.G. (2018) NMDAR-dependent Argonaute 2 phosphorylation regulates miRNA activity and dendritic spine plasticity. The EMBO Journal.

Parkinson G.T., Chamberlain S.E.L.,  Jaafari N., Turvey M., Mellor J.R. and  Hanley J.G. (2018) Cortactin regulates endo-lysosomal sorting of AMPARs via direct interaction with GluA2 subunit. Scientific Reports.


Smith K.R., Rajgor D., and Hanley J.G. (2017). Differential regulation of the Rac1 GTPase activating protein (GAP) BCR during oxygen/glucose deprivation in hippocampal and cortical neurons. The Journal of Biological Chemistry.

Koszegi Z., Fiuza M., and Hanley J.G. (2017). Endocytosis and lysosomal degradation of GluA2/3 AMPARs in response to oxygen/glucose deprivation in hippocampal but not cortical neurons. Scientific Reports.

Fiuza M., Rostosky C.M., Parkinson G.T., Bygrave A.M., Halemani N., Baptista M., Milosevic I., and Hanley J.G. (2017). PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 α-appendage and dynamin. Journal of Cell Biology.

Rajgor D, Fiuza M, Parkinson GT, Hanley JG. (2017). PICK1 Ca2+ Sensor Modulates NMDA Receptor-Dependent MicroRNA-Mediated Translational Repression in Neurons. The Journal of Biological Chemistry 292(23):9774-9786.


Cockbill LM, Murk K, Love S, Hanley JG (2015) Protein interacting with C kinase 1 suppresses invasion and anchorage-independent growth of astrocytic tumor cells. Molecular Biology of the Cell 26:4552-6.


Blanco-Suárez E, Fiuza M, Liu X, Chakkarapani E, Hanley J.G. (2014). Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation. The Journal of Cerebral Blood Flow and Metabolism 34:1898-906.

Antoniou A., Baptista M., Carney N.C. and Hanley J.G. (2014). PICK1 links Argonaute 2 to endosomes in neuronal dendrites and regulates miRNA activity. EMBO Reports 15:548-56.
Blanco-Suárez E. and Hanley J.G. (2014). Distinct Subunit-specific α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Trafficking Mechanisms in Cultured Cortical and Hippocampal Neurons in Response to Oxygen and Glucose Deprivation. The Journal of Biological Chemistry 289:4644-51.

Hanley J.G. (2014). Actin-dependent mechanisms in AMPA receptor trafficking. Frontiers in Cellular Neuroscience, 8:381. REVIEW.

Hanley JG. (2014). Subunit-specific trafficking mechanisms regulating the synaptic expression of Ca2+-permeable AMPA receptors. Seminars in Cell and Developmental Biology, 27:14-22. REVIEW.


Murk K., Blanco Suarez E.M., Cockbill L.M.R., Banks P., and Hanley J.G. (2013). The antagonistic modulation of Arp2/3 activity by N-WASP/WAVE2 and PICK1 defines dynamic changes in astrocyte morphology. Journal of Cell Science 126:3873-83.

Rocca D.L., Amici A., Antoniou A., Blanco Suarez E., Halemani N., Murk K., McGarvey J., Jaafari N., Mellor J.R., Collingridge G.L., and Hanley J.G. (2013).  The small GTPase Arf1 regulates Arp2/3-mediated actin polymerization via PICK1 to control synaptic plasticity.  Neuron 79:293-307.


Jaafari, N., Henley, J.M., and Hanley, J.G. (2012). PICK1 mediates transient synaptic expression of GluA2-lacking AMPARs during glycine-induced AMPA receptor trafficking. Journal of Neuroscience 34, 11618-30.


Dennis S.H., Jaafari N., Cimarosti H., Hanley J.G., Henley J.M., and Mellor J.R. (2011). Oxygen/Glucose Deprivation Induces a Reduction in Synaptic AMPA Receptors on Hippocampal CA3 Neurons Mediated by Metabotropic Glutamate Receptor 1 and A3 Receptors. Journal of Neuroscience 31, 11941-52.
Nakamura Y., Wood C.L., Patton A.P., Jaafari N., Henley J.M., Mellor J.R., and Hanley J.G. (2011). PICK1 inhibition of the Arp2/3 complex controls dendritic spine size and synaptic plasticity. The EMBO Journal, 30:719-30.


Hanley JG. (2010). Endosomal sorting of AMPA receptors in hippocampal neurons. Biochemical Society Transactions, 38: 460-465. REVIEW.


Dixon R.M., Mellor J.R. and Hanley J.G. (2009). PICK1-Mediated Glutamate Receptor Subunit 2 (GluR2) Trafficking Contributes To Cell Death In Oxygen/Glucose Deprived Hippocampal Neurons. The Journal of Biological Chemistry, 284: 14230-5.


Rocca D.L., Martin S., Jenkins E.L. and Hanley J.G. (2008). Inhibition of Arp2/3-mediated actin polymerisation by PICK1 regulates neuronal morphology and AMPA receptor endocytosis. Nature Cell Biology, 10: 259-271.

Hanley JG. (2008). AMPA receptor trafficking pathways and links to dendritic spine morphogenesis. Cell Adhesion and Migration, 2: 276-82. REVIEW.

Hanley J.G. (2008). PICK1: a multi-talented modulator of AMPA receptor trafficking. Pharmacology and Therapeutics, 118: 152-60. REVIEW.


Hanley J.G. (2007). NSF Binds Calcium to Regulate its Interaction with AMPA Receptor Subunit GluR2. Journal of Neurochemistry, 101: 1644-50.


Hanley J.G., and Henley J.M. (2005).  PICK1 is a calcium-sensor for NMDA-induced AMPA receptor trafficking. The EMBO Journal, 24: 3266-78.


Hanley J.G., Khatri L., Hanson P.I., and Ziff E.B (2002).  NSF ATPase and a/b SNAPs disassemble the AMPA receptor-PICK1 complex. Neuron, 34: 53-67.


Billups D*., Hanley J.G*., Orme M., Attwell D., and Moss S.J. (2000). GABAC receptor sensitivity is modulated by interaction with MAP1B. Journal of Neuroscience, 20: 8643-8650.
* 1st equal authorship

Hanley J.G., Jones E.M., and Moss S.J. (2000). GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1. Journal of Biological Chemistry, 275: 840-846.


Hanley J.G., Koulen P., Bedford F., Gordon-Weeks P.R., and Moss S.J. (1999). The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses. Nature, 397: 66-69.