Publications


Key publications from our lab:

2018

Rajgor D., Sanderson T.M., Amici M., Collingridge G.L., and Hanley J.G. (2018) NMDAR-dependent Argonaute 2 phosphorylation regulates miRNA activity and dendritic spine plasticity. The EMBO Journal. https://www.ncbi.nlm.nih.gov/pubmed/29712715

Parkinson G.T., Chamberlain S.E.L.,  Jaafari N., Turvey M., Mellor J.R. and  Hanley J.G. (2018) Cortactin regulates endo-lysosomal sorting of AMPARs via direct interaction with GluA2 subunit. Scientific Reports. https://www.ncbi.nlm.nih.gov/pubmed/29515177


2017

Smith K.R., Rajgor D., and Hanley J.G. (2017). Differential regulation of the Rac1 GTPase activating protein (GAP) BCR during oxygen/glucose deprivation in hippocampal and cortical neurons. The Journal of Biological Chemistry.  https://www.ncbi.nlm.nih.gov/pubmed/29046349

Koszegi Z., Fiuza M., and Hanley J.G. (2017). Endocytosis and lysosomal degradation of GluA2/3 AMPARs in response to oxygen/glucose deprivation in hippocampal but not cortical neurons. Scientific Reports. https://www.ncbi.nlm.nih.gov/pubmed/28951554

Fiuza M., Rostosky C.M., Parkinson G.T., Bygrave A.M., Halemani N., Baptista M., Milosevic I., and Hanley J.G. (2017). PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 α-appendage and dynamin. Journal of Cell Biology. https://www.ncbi.nlm.nih.gov/pubmed/28855251

Rajgor D, Fiuza M, Parkinson GT, Hanley JG. (2017). PICK1 Ca2+ Sensor Modulates NMDA Receptor-Dependent MicroRNA-Mediated Translational Repression in Neurons. The Journal of Biological Chemistry 292(23):9774-9786. https://www.ncbi.nlm.nih.gov/pubmed/28404816


2015

Cockbill LM, Murk K, Love S, Hanley JG (2015) Protein interacting with C kinase 1 suppresses invasion and anchorage-independent growth of astrocytic tumor cells. Molecular Biology of the Cell 26:4552-6. https://www.ncbi.nlm.nih.gov/pubmed/26466675


2014

Blanco-Suárez E, Fiuza M, Liu X, Chakkarapani E, Hanley J.G. (2014). Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation. The Journal of Cerebral Blood Flow and Metabolism 34:1898-906. https://www.ncbi.nlm.nih.gov/pubmed/25248834

Antoniou A., Baptista M., Carney N.C. and Hanley J.G. (2014). PICK1 links Argonaute 2 to endosomes in neuronal dendrites and regulates miRNA activity. EMBO Reports 15:548-56. https://www.ncbi.nlm.nih.gov/pubmed/24723684
         
Blanco-Suárez E. and Hanley J.G. (2014). Distinct Subunit-specific α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Trafficking Mechanisms in Cultured Cortical and Hippocampal Neurons in Response to Oxygen and Glucose Deprivation. The Journal of Biological Chemistry 289:4644-51. https://www.ncbi.nlm.nih.gov/pubmed/24403083

Hanley J.G. (2014). Actin-dependent mechanisms in AMPA receptor trafficking. Frontiers in Cellular Neuroscience, 8:381. REVIEW. https://www.ncbi.nlm.nih.gov/pubmed/25429259

Hanley JG. (2014). Subunit-specific trafficking mechanisms regulating the synaptic expression of Ca2+-permeable AMPA receptors. Seminars in Cell and Developmental Biology, 27:14-22. REVIEW.  https://www.ncbi.nlm.nih.gov/pubmed/24342448

2013

Murk K., Blanco Suarez E.M., Cockbill L.M.R., Banks P., and Hanley J.G. (2013). The antagonistic modulation of Arp2/3 activity by N-WASP/WAVE2 and PICK1 defines dynamic changes in astrocyte morphology. Journal of Cell Science 126:3873-83. https://www.ncbi.nlm.nih.gov/pubmed/23843614

Rocca D.L., Amici A., Antoniou A., Blanco Suarez E., Halemani N., Murk K., McGarvey J., Jaafari N., Mellor J.R., Collingridge G.L., and Hanley J.G. (2013).  The small GTPase Arf1 regulates Arp2/3-mediated actin polymerization via PICK1 to control synaptic plasticity.  Neuron 79:293-307. https://www.ncbi.nlm.nih.gov/pubmed/23889934


2012

Jaafari, N., Henley, J.M., and Hanley, J.G. (2012). PICK1 mediates transient synaptic expression of GluA2-lacking AMPARs during glycine-induced AMPA receptor trafficking. Journal of Neuroscience 34, 11618-30. https://www.ncbi.nlm.nih.gov/pubmed/22915106


2011

Dennis S.H., Jaafari N., Cimarosti H., Hanley J.G., Henley J.M., and Mellor J.R. (2011). Oxygen/Glucose Deprivation Induces a Reduction in Synaptic AMPA Receptors on Hippocampal CA3 Neurons Mediated by Metabotropic Glutamate Receptor 1 and A3 Receptors. Journal of Neuroscience 31, 11941-52. https://www.ncbi.nlm.nih.gov/pubmed/21849555
           
Nakamura Y., Wood C.L., Patton A.P., Jaafari N., Henley J.M., Mellor J.R., and Hanley J.G. (2011). PICK1 inhibition of the Arp2/3 complex controls dendritic spine size and synaptic plasticity. The EMBO Journal, 30:719-30. https://www.ncbi.nlm.nih.gov/pubmed/21252856


2010

Hanley JG. (2010). Endosomal sorting of AMPA receptors in hippocampal neurons. Biochemical Society Transactions, 38: 460-465. REVIEW. https://www.ncbi.nlm.nih.gov/pubmed/20298203


2009

Dixon R.M., Mellor J.R. and Hanley J.G. (2009). PICK1-Mediated Glutamate Receptor Subunit 2 (GluR2) Trafficking Contributes To Cell Death In Oxygen/Glucose Deprived Hippocampal Neurons. The Journal of Biological Chemistry, 284: 14230-5. https://www.ncbi.nlm.nih.gov/pubmed/19321442


2008

Rocca D.L., Martin S., Jenkins E.L. and Hanley J.G. (2008). Inhibition of Arp2/3-mediated actin polymerisation by PICK1 regulates neuronal morphology and AMPA receptor endocytosis. Nature Cell Biology, 10: 259-271. https://www.ncbi.nlm.nih.gov/pubmed/18297063

Hanley JG. (2008). AMPA receptor trafficking pathways and links to dendritic spine morphogenesis. Cell Adhesion and Migration, 2: 276-82. REVIEW. https://www.ncbi.nlm.nih.gov/pubmed/19262155

Hanley J.G. (2008). PICK1: a multi-talented modulator of AMPA receptor trafficking. Pharmacology and Therapeutics, 118: 152-60. REVIEW. https://www.ncbi.nlm.nih.gov/pubmed/18353440

2007

Hanley J.G. (2007). NSF Binds Calcium to Regulate its Interaction with AMPA Receptor Subunit GluR2. Journal of Neurochemistry, 101: 1644-50. https://www.ncbi.nlm.nih.gov/pubmed/17302911


2005

Hanley J.G., and Henley J.M. (2005).  PICK1 is a calcium-sensor for NMDA-induced AMPA receptor trafficking. The EMBO Journal, 24: 3266-78. https://www.ncbi.nlm.nih.gov/pubmed/16138078


2002

Hanley J.G., Khatri L., Hanson P.I., and Ziff E.B (2002).  NSF ATPase and a/b SNAPs disassemble the AMPA receptor-PICK1 complex. Neuron, 34: 53-67. https://www.ncbi.nlm.nih.gov/pubmed/11931741


2000

Billups D*., Hanley J.G*., Orme M., Attwell D., and Moss S.J. (2000). GABAC receptor sensitivity is modulated by interaction with MAP1B. Journal of Neuroscience, 20: 8643-8650. https://www.ncbi.nlm.nih.gov/pubmed/11102469
* 1st equal authorship

Hanley J.G., Jones E.M., and Moss S.J. (2000). GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1. Journal of Biological Chemistry, 275: 840-846. https://www.ncbi.nlm.nih.gov/pubmed/10625616


1999

Hanley J.G., Koulen P., Bedford F., Gordon-Weeks P.R., and Moss S.J. (1999). The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses. Nature, 397: 66-69. https://www.ncbi.nlm.nih.gov/pubmed/9892354
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